Glucophage information and description. Glucophage is a trade name for the oral anti-hyperglycemic agent metformin HCL. Glucophage is generally used in the management of mature onset (Type-Il) diabetes and utilized when dietary management and exercise alone have not been able to control the disease, yet injectable insulin is not appropriate since this hormone is still present in the body. While the main activity of Glucophage (metformin HCL) is the increased utilization of glucose, it does not directly mimic the action of insulin

Glucophage side effects. While Glucophage is considered much safer than insulin, it is not without own unique risks. The most serious complication is the possible development of lactic acidosis. This is an often-fatal metabolic disorder involving (among other factors) an increase in lactate levels (lactic) and a pronounced decrease in blood pH (acidosis). The package insert of Glucophage displays the additional warning: the administration of oral hypoglycemics may be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet with insulin. The risk for severe side effects of Glucophage are increased in people suffering from liver dysfunction or who drink excessive alcohol. Or those with renal dysfunction, noting impaired creatine clearance (a serum concentration above 1,2mg per 100 ml is considered the cut-off point for treatment). A number of other “minor” side effects of Glucophage may include, but are not limited to, anorexia, nausea, vomiting, diarrhea, metallic taste, fatigue, weakness and malabsorbtion of vitamin B12. Quite often these side effects effects will subside if the dosage of Glucophage (metformin HCL) is lowered.

When administered, the absorption rate of Glucophage (metformin HCL) is very slow. Metformin HCL will make its way to circulation slowly, over a period of about six hours. The general intake schedule among bodybuilders is to take 850mg (one tablet) twice per day. The user will be sure to additionally supplement with a carbohydrate replacement (such as Ultra Fuel) and with creatine monohydrate, particularly after periods of training. The result of Glucophage's treatment will probably not be as dramatic as when using insulin, but a notable anabolic effect can be achieved nonetheless. Most athletes opt to use this drug for a limited duration, cycles of Glucophage usually lasting only a couple of months. This would be followed by an equally long break (at a minimum).

The concept of harnessing insulin for performance enhancement has been catching on in recent years. As you may know, insulin is considered a “storage hormone”. Injectable insulin can be extremely risky however, an incorrect dosage or insufficient carbohydrate intake having grave consequences to the user’s health. In extreme cases, hypoglycemia (low blood sugar) can lead to coma or even death. Since this effect is rare with Glucophage, it is considered by many athletes to be an introduction to insulin manipulation.

This drug heightens the body's sensitivity to insulin, and is currently used to treat type 2 diabetes. For fat loss purposes Metformin is used in ketogenic diets to rapidly drop blood sugar to quickly induce ketosis. For a mixed ratio diet, Metformin would be used with carb meals insuring that the carbohydrates go to muscle tissue over fat, this is a great addition to a high sugar post workout meal.

Additionally, due to the fact that it controls insulin levels in the body, it also greatly reduces hunger in between meals. Metformin is very beneficial in that it heightens insulin sensitivity, which is very good due to the fact that most Americans are insulin insensitive. This over production of insulin which insulin insensitivity causes can lead to weight gain and also various other health problems. Now, the best way to use Metformin would be to take 2000-3000mg divided up with meals. On a moderate carb diet, you could split up the dose and take it only with your carb meals.

If you follow a CKD (cyclic ketogenic diet) type diet, the best way to use it would be with your weekend carb up, which would follow the same schedule as above. Metformin is not needed during the week, but if you like the appetite suppressing effects that it gives you, you can also use it during the week. Another thing you can do on a CKD is to have a small amount of fast acting carbs (around 40-50g) after your workout with Metformin. This will not cause you to drop out of ketosis due to the fact that the Metformin will quickly shuttle the carbohydrates into the muscle cells while still running on ketones.

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